I cannot speak for major wounds. My experience was once with a scar from a stitch on a soft skin area and the second time with a small scratch on my face from my pet. Both scars were small in size, like a pimple. And both times, I felt that this cream did nothing. Apart from protecting the surface of the wound, the healing process did not improve at all. Especially with the scratch, I thought it would help heal faster than the stitch, but I did not see the scar fading away, but rather it was delayed. The stitch, when I stopped using it, started to discolor. I do not know about large scars, I repeat. Expensive cream... Maybe A derma duo would be more beneficial, as it promotes regeneration and helps with discoloration.